目的 報告多孔磷酸三鈣 ( tricalcium phosphate，TCP ) 治療 38 例腔隙性骨缺損患者至少隨訪 2 年的臨床效果。方法 2008 年 3 月至 2011 年 9 月，對 38 例腔隙性骨缺損患者採用多孔磷酸三鈣填充修復，男 22 例，女 16 例。年齡 3～58 歲，平均 23 歲。缺損範圍最小 0.72 cm3，最大 151.88 cm3，平均 濟南軍區總醫院骨病科許宋鋒
35.62 cm3。隨訪 25～65 個月，平均 41 個月。採用在體 TCP 人工骨降解的 X 線片並影象分析軟體分析植骨區灰度變化，計算材料降解率，動態觀察多孔磷酸三鈣人工骨降解情況。結果 所有患者術後未見任何過敏或毒性反應。隨時間延長，人工骨材料逐漸降解，新骨逐漸形成，以術後 1 年內降解速度最快。患者年齡越小 ( ＜16 歲 )、腫瘤體積越小 ( ＜10 cm3 )，新骨成骨、材料降解速度越快。結論 多孔磷酸三鈣人工骨可以用作良性或侵襲性骨腫瘤骨缺損的修復，平均隨訪 41 個月，療效滿意。
Objective To assess the over-2-year clinical outcomes of porous tricalcium phosphate ( TCP ) for the repair of lacunar bone defects. Methods A total of 38 patients with lacunar bone defects underwent the repair with porous TCP from March 2008 to September 2011, including 22 males and 16 females, whose average age was 23 years old ( range; 3-58 years ). Tumor sizes varied from 0.72 cm3 to 151.88 cm3, with the average size of 35.62 cm3. All patients were followed up for a mean period of 41 months ( range; 25-65 months ). The in vivo biodegradation rate of the implanted TCP was evaluated based on the radiographic analyzing method. The gray scale change of the grafting area in plain X-ray images was used to assess the degradation of porous TCP. Results
There was neither significant reverse reaction to the transplanted material nor locally inflammatory reaction in all of the cases. Bone defects were repaired gradually, in company with the degradation of TCP materials and the formation of new bone. The rates of TCP degradation and new bone formation were fastest in the first year postoperatively. The younger the patients were ( <16 years old ) and the smaller the tumor size was ( <10 cm3 ), the faster the rates were.Conclusions The porous TCP is an ideal material for the repair of lacunar bone defects caused by benign or invasive tumors, and the over-2-year follow-up results are satisfactory .
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